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In fact, UVR-activated p53 promotes apoptosis through transcriptional activation of pro-apoptotic genes, such as p53-upregulated modulator of apoptosis ( PUMA) [41] and phorbol-12-myristate-13-acetate-induced protein 1 ( PMAIP1 ) (encoding NOXA protein) [41], which bind and inhibit the pro-survival BCL-2 proteins, such as BCL-2, BCL-XL, and Myeloid Cell Leukemia 1 (MCL-1) [42], thereby unleashing the pro-apoptotic effectors BCL-2-associated X protein (BAX), BCL-2 Antagonist/Killer (BAK), and Bcl-2-antagonist of cell death (BAD)

Verse 1 In the opening verse, Bryan admits he has been emotionally closed off for a long time, singing, "Well, I ain't written a love song in so long as your hair leads down your spine," showing that moments of intimacy can still pull him back into vulnerability

J Cell Sci 129(23):43294339

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