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These claims are used to describe 1) that the product is made with nicotine created in a lab (i.e., tobacco-free nicotine, also known as synthetic nicotine or non-tobacco nicotine), or 2) that the product contains no tobacco leaf (i.e., tobacco-free or tobacco leaf-free)

*Correspondence: Esteban Ortiz-Prado, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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