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Additional hypotheses include the rapid correction of glycemia following GLP-1 RA administration, similar to the exacerbation of DR, as well as long-term effects of prior hyperglycemia via persistent changes in endothelial gene expression, often referred to as glucose memory [198,199]

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Unmeasured confounding variables such as socioeconomic status, environmental sleep conditions, or unrecorded psychiatric comorbidities may have influenced the observed associations