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34,37 The requirement for local metabolic activation of NNK in the mouse lung has been elegantly demonstrated by experiments using mice in which cytochrome P450-reductase, the requisite co-factor for cytochrome P450-catalyzed metabolic activation of NNK, has been knocked out in the lung, 38 and a polymorphism in Cyp 2A5 decreased NNK-induced DNA adduct formation and lung tumorigenesis, as seen in parallel epidemiologic studies of lung cancer

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But if you prioritize convenience and speed, cigarette tobacco remains the standard choice

The National party declined to answer the BBC's questions about political funding from tobacco companies

When health concerns about cigarettes began to receive public attention in the 1930s, tobacco companies took preemptive action