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IL-6 mediates the JAKSTAT pathway, resulting in STAT3 phosphorylation, promoting neutrophil adhesion and migration to the lungs, releasing neutrophil elastase and matrix metalloproteinase-9, causing emphysema and COPD

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Cancer Res 27, 51315140 (2021)
Anti-inflammatory IL-10 was decreased in the groups exposed to vapor and smoke ( Supplementary Tables S1 , S2 )

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