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SURMOUNT-1 Investigators

doi:10.3389/fendo.2021.576412 96

43 The superiority of oral semaglutide in reducing HbA1c was observed as early as at week 26

But the clinical stakes extend considerably further

Early clinical and anecdotal reports are promising, yet robust long-term evidence for their anti-aging claims is still limited, and experts caution that these medications should be used thoughtfully, under medical guidance, until more research confirms their safety and effectiveness for this purpose.

But persistent or severe fatigue deserves attention especially if its paired with red-flag symptoms or dehydration signs