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So the medical answer here is pretty boring

DNA methylation aberrations are also more easily induced in males than females by early environments, such as prenatal exposure to cigarette smoke or a lack of folate ( Taken together, DNA methylation at any given CpG is the result of multiple processes that are orchestrated as a developmental cascade involving, first, global demethylation after fertilization, then, cell/tissue-specific re-methylation during very early embryogenesis and, finally, maintenance of DNA methylation throughout the remainder of life

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