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Dose reduction was required in 12.5% of patients, mostly owing to gastrointestinal symptoms, and discontinuation for any reason occurred in 5.5%

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Mechanistically, these effects are linked to GLP-1 RA-mediated suppression of inflammatory pathways, modulation of skeletal muscle metabolism, and preservation of mitochondrial function, thereby influencing insulin resistance

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Headaches affect some people starting Wegovy or other GLP-1 medications

Grand Junction is located along the Colorado River, where it receives the Gunnison River from the south, giving the city its nickname River City