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Patients The first and last patient started trial therapy on June 7th 2018, and December 2nd 2020, respectively

The disease is characterized by organ overgrowth and the formation of fluid-filled cysts that displace/replace normal renal tissue eventually leading to end-stage renal disease and renal failure

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Once AMD reaches an advanced stage, blood vessels grow from underneath the macula and leak blood and fluid into the retina, eventually forming a scar and leading to permanent loss of central vision [152]

Timing Baseline Marker Lipid panel Why it matters Tracks cardiometabolic changes during recomposition and weight-loss phases