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Because tobacco had become the mainstay of the Virginia and Maryland economies, plantations were established by riverbanks for the good soil and to ensure ease of transportation

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But there is concern over the effects it might have on heart health, since it raises blood pressure

The complexity, fragmentation, and evolution of this sector strongly suggest the need for a comprehensive framework to understand and monitor it, including its potential associations with the broader tobacco industry and its implications for public health in the US