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Hypertension management in patients with chronic kidney disease

Adults with biopsy-proven MASH and fibrosis stage F1F2F3, with or without type 2 diabetes, and with MRI-PDFF 8% at screening are randomised 1:1:1:1 to efocipegtrutide 2, 4, and 6 mg once-weekly subcutaneously or placebo for 52 weeks (estimated enrolment: N = 240)

SDF: stromal cell-derived factor

Both medications are effective, but they work slightly differently

In the SUSTAIN clinical trial program evaluating subcutaneous semaglutide for type 2 diabetes, once-weekly dosing (0.5 mg or 1.0 mg) reduced HbA1c by 1.5% to 1.8% from baseline, with superior glycemic control compared to specific comparators in head-to-head trials (SUSTAIN-7 vs dulaglutide

The clinical reality is that GLP-1s produce meaningful cardiovascular and metabolic benefits beyond weight loss, yet access remains fragmented by insurance type and state policy