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Because the estimate had a wide confidence interval, we opted to begin the main study with an adaptive design (Chow & Chang, 2011)

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The brain ends up needing more nicotine

Revenue rose from $4.53 billion in 2019 to $4.82 billion in 2020, the FTC said

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Though the study found that smokers were more likely than non-smokers to have lung cancer, and that the prevalence of the disease rose with the quantity smoked, the design of the study still left room for Fishers dreaded confounding problem