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The Investigators were not blinded to allocation during experiments and outcome assessment, besides measurements of max cristae width which were performed in a blinded fashion to prevent biased outcomes

This is consistent with previous studies linking glutamine levels to gene expression via KG-mediated epigenetic reprogramming 25,26

identified mitophagy as an intrinsic vulnerability in CRC cells subjected to statin treatment, revealing how disruption of mitochondrial homeostasis, shaped by distinct metabolic contexts, leads to cell death and therapeutic sensitivity [103] Spatial heterogeneity across colorectal tumor sites underlies distinct metabolic phenotypes [104]

It can covalently bind to the cysteinyl thiol residues of proteins through an autooxidation mechanism, thereby inhibiting those proteins [88]

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This uncertainty cannot be resolved without longitudinal human data that does not currently exist