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Mutual Reinforcement : Both substances influence dopamine release, potentially reinforcing each others effects and increasing the likelihood of co-use

We know that recommended approaches such as nicotine replacement therapy or prescription medications can increase smoking cessation, but only about one-third of people trying to quit use one of these approaches, White says

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Instead, the lower prevalence observed among exclusive e-cigarette users may reflect factors such as age, body weight, lifestyle characteristics, prior smoking history, healthcare engagement, or other residual confounding variables
