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Additionally, previous studies have shown that p53 gene polymorphism was significantly related to the incidence of smoking-related COPD, and p53 protein was markedly increased in COPD smokers [150, 151]

Papers included were those written in English language and no end date was specified

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It also causes a slight adrenaline rush that speeds up your heart and raises blood pressure, some of the reasons the American Heart Association considers smoking a major risk factor for heart disease