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Inflammatory monocytes had increased microvascular adhesion and peri-vascular deposition of mononuclear cells, with NADPH oxidase (Nox2) and TLR4 deficits enhancing vascular reactivity and swelling with concentrated exposure to PM 2.5 (153, 175)

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Compared with non-smokers, tobacco-only smokers (but not cannabis-only smokers) experienced more frequent respiratory symptoms (odds ratio [OR] 1.50, 95% CI 1.052.14) and were more likely to have COPD (OR 2.74, 95% CI 1.664.52)

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