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Addiction and dependency Nicotine, a primary ingredient in e-cigarettes, can lead to addiction and dependency, as neuroadaptations can occur with the persistent use of nicotine (e.g., tolerance), withdrawal symptoms can be experienced when intake of nicotine is stopped, and the effects of nicotine that reinforce dependence [51]

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5 Myths About E-Cigarettes E-Cig vapor is safe or pure E-cigarette vapor usually contains nicotine as well as other potentially toxic chemicals that can lead to nicotine addiction or other serious health conditions