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Description
Part 1 of 2 covers the mechanism and the U/kg trend, the portal-peripheral mismatch, and the Ominous Octet framework

If symptoms worsen, clinicians can compare data to determine causality

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54, 95% CI 0.064.84)

(ii) improvement in insulin sensitivity, where and indices improve through the combined effects of weight loss and adipose tissue redistribution (78)

This is not a sign that the drug "stopped working." It reflects that the drug was doing the work, and without it, the underlying biology resumes
