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Canada first required health messages inside cigarette packages in 2001, either on an insert for flip-top packages, or on the "slide" of slide and shell packages

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526 (13), 3650 (2005) F.J

Governments are implementing stricter regulations on tobacco products, which may lead to changes in product formulations and marketing strategies

Rats were used in this study because rats have been shown to have a well-defined reproductive system and all the compounds, that have been used to cause anti-fertility effects in males have been found to be active in rats (24)