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While not completely safe, there are still short-term and long-term effects that are important to understand

A doctor tested the blood of 12 patients, who claimed to smoke one packet of cigarettes per day, for cotinine

Participants may also have misreported their use of tobacco products or caffeine as well as their depressive symptoms regardless of the survey's anonymity

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By 2020, sales of e-cigarettes are projected to overtake sales of traditional cigarettes

Nicotine is known to rapidly metabolize into cotinine and OH-Cotinine, indirectly contributing to more heightened ROS accumulation 53,54