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In 2018 FDA Tobacco Product Scientific Advisory Committee found that the IQOS did not substantially reduce risks of tobacco-related death and disease, and in 2019, FDA did not approve the products for a risk modification label

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The haze of smoke swirls, infusing the scene with an air of mystery and thoughtfulness

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Potential harm due to flavor chemicals is further supported by an in vitro study in which maltol increased secretion of IL-8 from BEAS-2B cells and decreased barrier function in human bronchial epithelial cells 30 and by animal studies in which maltol produced long-term adverse health effects in rats and dogs 31 and elicited liver and kidney damage in mice 32