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I feel confident that in this case we could identify this group of substances, and it would be worth almost any effort, by preliminary treatment, additives, or filtration, to get rid of it." Industry documents show that tobacco companies focused their safe-cigarette research on several areas, including the development of synthetic tobacco, boosting nicotine levels in low-tar cigarettes (so smokers wouldn't have to compensate for a loss of nicotine), and selective filtration of the most toxic substances in cigarette smoke, such as carbon monoxide