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The review notes that while some pouch ingredients are Generally Recognized as Safe (GRAS) food substances, long-term oral exposure effects remain under-studied

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As a consequence of our improved understanding of FosB in addiction, it is possible to evaluate the addictive potential of current medications (119), as well as use it as a biomarker for assessing the efficacy of therapeutic interventions (121,122,124)

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This indicates that the addition of marijuana to e-cigarettes may have an impact on the hyperarousal dimension of anxiety