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INTRODUCTION Recent efforts to achieve higher smoking cessation rates have turned to combination pharmacotherapies (CP) for nicotine dependence.(1-3) Initial efforts at developing CPs focused on existing nicotine replacement therapies (NRTs), most commonly coupling the nicotine patch and an ad libitum system (i.e., nicotine gum, lozenge, inhaler, or nasal spray)

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The cessation benet is not limited to young and middle-aged adults who smoke

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First, historical data shows significantly higher smoking prevalence among men (global average 37.5%) compared to women (8.4%) (11)