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To view a copy of this licence, visit About this article Cite this article Omolaoye, .S., El Shahawy, O., Skosana, B.T

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Summary and future perspectives p53 is a crucial tumour suppressor that protects cells from malignant transformation by activating a range of cellular responses, including apoptosis, adaptation of cellular metabolism, cell cycle arrest, cell senescence and DNA damage repair

Once in the body, it can lead to various short- and long-term health concerns

Interestingly, in colon cancer, mutp53 selectively releases miR-1246-rich exosomes that are taken up by surrounding macrophages, leading to miR-1246-dependent reprogramming into a tumor-promoting M2 state [92]