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Pharmacology & Toxicology

doi: 10.3390/antiox8120569

Hence, some antineoplastic drugs/targets have been constructed/considered to antagonize MDM2, independent of p53

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A dynamic role of HAUSP in the p53Mdm2 pathway

Mechanistically, we found that overexpression of miR-34a-5p significantly reduced protein levels of HNF4 and CYP3A11, leading to a decrease in the severity of APAP-induced ALI