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It is intended to be administered by intramuscular injection

10.1002/emmm.201200245 [DOI] [PMC free article] [PubMed] [Google Scholar] Bischoff-Ferrari HA, Gngler S, Wieczorek M, Belsky DW, Ryan J, Kressig RW, Sthelin HB, Theiler R, Dawson-Hughes B, Rizzoli R, Vellas B, Rouch L, Guyonnet S, Egli A, Orav EJ, Willett W, Horvath S (2025) Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial

By inhibiting NNMT and preserving NAD, 5-Amino-1MQ indirectly boosts SIRT1 activity , leading to: Increased fat oxidation SIRT1 activates PGC-1 (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a master regulator of mitochondrial biogenesis and fat metabolism

[14] found that mice with NNMT knockdown have lower levels of fasting glucose and lower pyruvate conversion to glucose compared to control mice

Mullis PE, Pal BR, Matthews DR, Hindmarsh PC, Phillips PE, Dunger DB: Half-life of exogenous growth hormone following suppression of endogenous growth hormone secretion with somatostatin in type I (insulin-dependent) diabetes mellitus

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