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In other words: Receptor overstimulation from rapid dose increases is the primary driver of gastrointestinal adverse events, not the compound itself when used therapeutic doses

Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

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Patience during the escalation phase pays dividends in long-term adherence and outcomes

These usually dissipate as the medication is absorbed

Patients with active eating disorders or a psychiatric history involving disordered eating patterns require careful screening and may benefit from concurrent mental health support rather than GLP-1 monotherapy