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[85] The ability to quit smoking is affected by genetic factors, including genetically based differences in the way nicotine is metabolized

[93:01] Davey Wester Yeah

When you inhale smoke, carbon monoxide (like car exhaust), TSNAs and PAHs are deposited on your red blood cells, too, and are then carried throughout your body

So even if the nicotine content seems similar, the health impact is very different

Conclusions In this review we provided a summary on the possible health-risks associated with e- cigarette use among adolescents and young-adults from a molecular biology perspective, focusing on basic science such as DNA repair, signaling pathways, and immunological responses

"Flavoured, non-cigarette tobacco for sale in the USA: an inventory analysis of Internet retailers" (PDF)