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This 20th Century hookworm mutating into a 21st Century drug-resistant hookworm can become a big problem because of dog parks, boarding kennels, and other places where dogs congregate

At the molecular level, a reduction in the expression of HLA-DR on the surface of peripheral-blood mononuclear cells has been described, as well as a higher frequency of allele QBP 5.12 in the promoter of the gene HLA-DQB1 in patients under exacerbation 149

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