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273309, doi:10.2307/2843888, JSTOR 2843888 Medical History , 6 (1): 6772, doi:10.1017/s0025727300026867, PMC 1034674, PMID 14488739 Sydenham, Thomas (1809), "Schedula Monitoria, or an Essay on the Rise of a New Fever", in Benjamin Rush (ed.), The works of Thomas Sydenham, M.D., on acute and chronic diseases: with their histories and modes of cure , Philadelphia: B

Heavy alcohol use (more than three alcoholic drinks daily) during pregnancy increases the risk of spontaneous abortion by more than threefold

Alcohol, cigarette smoke, and drugs, which have proven adverse effects on fully developed humans, are even more detrimental to a developing fetus

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Ethics declarations Ethics approval Ethics approval was obtained from Hunter New England Local Health District Human Research Ethics Committee (16/11/16/4.07), The University of Newcastle Human Research Ethics Committee (H-2017-0032) and Aboriginal Health and Medical Research Council (1236/16)

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