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EDSs are due to a mutation in one of more than a dozen different genes

Separate the reconstitution step from later dose withdrawal

Neuropathic pain often disrupts sleep, creating a vicious cycle where poor sleep impairs healing while nerve damage disrupts sleep

Individuals in stage 3 perform daily life activities independently but cognitive difficulties may make it hard to perform complex activities of daily living (i.e., they may require more time to complete a task or may be less efficient in completing a task, but they are able to complete it)