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Severe or prolonged gastrointestinal symptoms can lead to dehydration and electrolyte imbalances, including hypokalaemia (low potassium)
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Other confirmatory secondary endpoints for all the trials are change from baseline to EOT (or change from randomization [week 20] to EOT for the sustained WM trial [STEP 4]), in waist circumference (centimeters), systolic blood pressure (millimeters of mercury), and clinical outcome assessments
Serious but rare side effects require immediate medical attention: Pancreatitis : Severe, persistent abdominal pain that may radiate to the back, often accompanied by nausea and vomiting

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