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Mitochondrial changes in PBECs from COPD patients compared to PBECs from (never-) smoking individuals In order to assess whether long-term smoking also results in (persistent) structural changes in epithelial mitochondria in COPD, we studied mitochondrial alterations in PBECs derived from severe ex-smoking COPD GOLD stage IV patients and age-matched never-smoking and smoking controls

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Nicotine and the developing human: a neglected element in the electronic cigarette debate