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It can make the skin of a 40-year-old look like that of a nonsmoking 70-year-old

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I dont know that well ever be able to get the holdouts on this, Kelly told NOTUS

Nicotine is the notable ingredient in all tobacco products, including cigarettes, that causes physical, mental, and behavioral dependence and makes it hard to quit smoking

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Notably, the crude association for former smokers was substantially stronger (crude OR 1.59), indicating that the higher unadjusted prevalence in this group was largely explained by age and other confounders rather than by smoking history alone