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One major mechanistic pathway involves oxidative stress induced by ROS and reactive nitrogen species (RNS) present in cigarette smoke

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Owing to the overlapping clinical features with other diseases affecting the perianal region [23], HS must be differentially diagnosed from other diseases, including Crohns disease (CD) and pilonidal cysts

Support for authors was also provided by the National Institutes of Health (NIH) Grants R01DA051005 (Irina Stepanov), U54DA046060 (Andrea M