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doi: 10.1146/annurev.ph.56.030194.000521 21

The development of new strategies, including immune tolerance induction and vector engineering, may help overcome existing limitations [157]

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Furthermore, silymarin also inhibited the proliferation and proinflammatory cytokine (TNF-, Interferon- (IFN-), and IL- 2) secretion of T cells, intrahepatic expression of inducible nitric oxide synthase (iNOS) and intrahepatic NF-B activation [131,132,133,134,135]

[DOI] [PMC free article] [PubMed] [Google Scholar] [75].Blake MJ, Udelsman R, Feulner GJ, Norton DD, Holbrook NJ