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However, this regenerative response appears dysregulated, as reflected by abnormal growth patterns, emphasizing that persistent injury may drive both progenitor activation and exhaustion over time ( MSCs and EVs demonstrated potent immunomodulatory effects, reducing inflammatory infiltration and collagen deposition while normalizing organoid growth

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However, in multivariate models, retrospective estimates of consumption were no longer associated with cotinine levels, whereas EMA-based estimates retained their relationship to this biochemical marker

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