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[DOI] [PMC free article] [PubMed] [Google Scholar] Dent J., Holloway R

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The first study examined dogs affected by myxomatous mitral valve disease and found that individuals living in households with smokers exhibited statistically significantly lower plasma concentrations of tetrahydrobiopterin (p=0.01) [a cofactor for endothelial-derived vasodilator nitric oxide, whose depletion is associated with oxidative stress], suggesting that passive smoke exposure may contribute to oxidative imbalance 37

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cGAS, NLRP3, and TLR4 expression increased in cells incubated with 10% CSE compared to unexposed cells (Figure 6B)

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