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Consequentially, new targets for a possible new treatment of nicotine addiction could emerge from this research

Since introducing the WHO Framework Convention on Tobacco Control (FCTC) in 2005, outlining demand-reduction policies, many counties have witnessed drastic decreases in the prevalence of tobacco smoking 25

Apart from over 50 known human carcinogens (methylcholanthrene, benzo--pyrenes, acrolein) tobacco smoke contains toxins (carbon monoxide, ammonia, acetone, nicotine, hydroquinone), chemically reactive solids, and oxidants (superoxide, hydrogen peroxide, nitrogen oxides) [87,88]

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