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Its the third leading cause of death worldwide, with smoking being the major risk factor

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doi:10.1161/01.ATV.0000051384.43104.FC

There are few if any attempts, however, to systematically and comprehensively evaluate the landscape of evidence on smoking risk across a diverse range of health outcomes, with most current research focusing on risk or attributable burden of smoking for a specific condition 7,15 , thereby missing the opportunity to provide a comprehensive picture of the health risk experienced by smokers