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Recently, clinical trials of tirzepatide, a dual GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist, have achieved approximately 20% weight loss in substantial proportions of people with obesity (1)
88 It is important to note that both groups were resistant to other reproductive treatments, and weight loss was observed in both groups, indicating the potential existence of other mechanisms exerted by GLP-1RAs that improve pregnancy outcomes other than weight loss
In which case I have this little piece of advice, inspired by the great Willie Nelson: Mammas Dont Let Your Babies Grow Up to Be Bariatric Surgeons.
Months 6 to 12: The SURMOUNT-5 trial published in the NEJM in 2025 found tirzepatide produced 20.2% body weight loss compared to 13.7% for semaglutide over 72 weeks in patients with obesity
Ozempic Injection Site Reactions Injection site reactions are among the most common side effects of Ozempic and are usually mild and temporary
Postmenopausal women have low estradiol, elevated FSH, concomitant bone loss, and increased body fat)
