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17 Furthermore, in a model of inhalational tolerance, prolonged cigarette smoke exposure of mice significantly delayed the establishment of tolerance induced by repeated harmless antigen challenges

17 Insomnia can potentially be addressed by taking the first dose early in the morning and the second in the late afternoon (at least four hours before bedtime), or by reducing total daily intake to 150 mg

In truth, the negius of an addiction is so profound that it causes one to wonder if such an addict should be the one deciding if his addiction of choice is halachically acceptable (see, however, the amazing words of the Chazon Ish in Emunah UBitachon 3:30quoted in Shaarei Aharon to Devarim 16:19where he explains that often halachah does indeed allow one who has something to gain or lose from a psak to be the arbiter)
