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WHY CREATININE INCREASES 1 DECREASED KIDNEY FILTRATION (most important cause) When GFR (glomerular filtration rate) falls: Less filtration Creatinine not excreted Accumulates in blood Causes: Chronic kidney disease Acute kidney injury Glomerulonephritis Diabetic nephropathy Hypertensive nephrosclerosis 2 PRE-RENAL CAUSES (low kidney blood flow) Renal perfusion filtration Examples: Dehydration Shock Heart failure Severe blood loss Sepsis 3 POST-RENAL CAUSES (urinary obstruction) Urine outflow blocked back pressure GFR Examples: Prostate enlargement Kidney stones Tumor Ureteric obstruction
Different eras, different structural logic, different receptor fingerprints
The lifespan data of SOD1 G93A GPX4 mice and control SOD1 G93A mice are presented in Fig
Neutrophil counts were performed on all of the acquired images by a trained researcher under direct supervision of a pathologist
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10.7554/eLife.60030 [DOI] [PMC free article] [PubMed] [Google Scholar] Konishi H, Hio M, Kobayashi M, et al
