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While chronic infections with HBV and HCV, heavy alcohol consumption, and diabetes are well-established primary risk factors for HCC, there is compelling and growing evidence that prolonged and active cigarette smoking is an independent and significant risk factor for its development [98, 99]

38 Conclusion As e-cigarette use has only become a prevalent epidemic in the last decade, future research is needed to confirm the long-term effects

The testes and the scrotal area require oxygen transported by the blood to remain functional and viable, and the twisting may result in the "death" of a testicle

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(For a broader discussion of lung cancer, see The Future Of Healthcare Delivery For Lung Cancer published in Medical New Today on Feb 15, 2013 and available at )