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Description
Despite the obvious biologic plausibility, the lack of consistent epidemiological evidence might be due to methodological issues including lack of cohort follow-up time into older adulthood (when lung cancer usually becomes clinically manifest), small sample sizes, selection and recall biases, and lack of adjustment for tobacco use in the statistical modeling
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One area of debate is whether e-cigarette use entails a reduced risk of addiction in comparison to conventional tobacco cigarettes

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Moreover, the rapidly evolving nature of e-cigarette products and formulations means that some findings may not fully reflect current market trends or emerging devices
