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The targets of nicotine, nAChRs, are ligand-gated ion channels expressed in many tissues including microglia, neurons, and the epithelium of the airway and bloodbrain barrier 25

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In response, tobacco companies advertising campaigns suggested that smoking was a way to remain thin [For example, To keep a slender figure, no one can deny, reach for a Lucky instead of a sweet' The American Tobacco Company, 1929] and created brands to imply that one could have a svelte figure from cigarettes [Philip Morris Virginia Slims (1968) and The American Tobacco Companys Silva Thins (1967)]

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This translates to a high rate of people living in poverty (15.8%)