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FIGURE 6 FA-mediated downregulation of miR-34a-5p sensitizes APAP-induced hepatotoxicity in vitro To replicate our in vivo observations, we investigated whether treatment with CS ingredients such as DEN and FA (Smith et al., 2000), affected the severity of APAP-induced hepatocellular death by modulating miR-34a-5p expression in vitro using primary hepatocytes

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In some cases, more than two HDACs play opposite roles in regulating the inflammatory response, suggesting that pan-HDAC inhibitors may result in unwanted effects
p53: Traffic cop at the crossroads of DNA repair and recombination

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Phosphorylation modifications also affect sensitivity to radiotherapy