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Further oxidation of Hz and AcHz by CYP450 enzymes, particularly CYP2E1, generates reactive intermediates that form covalent adducts with endogenous macromolecules, a process implicated in INH-induced hepatotoxicity (Yue et al., 2004

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It is also important to emphasize that not all studies included in the prevalence analysis were included into association calculations, because most of them did not contain a control group of patients without headache