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Figure 1-4 reveals that between 1985 and 2003, smoking initiation rates among young adults increased 4.3 percent, from 64.7 per 1,000 individuals to 67.5 per 1000 (SAMHSA 2005)

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Critically, both combustible tobacco products and e-cigarettes contain nicotine, a highly addictive, plant-derived alkaloid that binds to nicotinic acetylcholine receptors (nAChR)

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Factors Associated with Smoking Initiation and Cessation Natural history of tobacco use Tobacco use can be characterized as a chronic disease that begins in childhood because nearly all cigarette smokers report that they smoked their first cigarette during adolescence and then continue to use tobacco for decades.(46) Over 80% of U.S